Humanin and Cardiovascular Diseases
نویسندگان
چکیده
Peptidy produkovanĂŠ mitochondriemi (mitochondrial-derived peptides, MDPs) jsou kĂłdovĂĄny mitochon- driĂĄlnĂ DNA. Mezi MDP patĹĂ humanin, ribosomĂĄlnĂ ribonukleovĂĄ kyselina typu c (ribosomal ribonucleic acid type c, MOTS-c) a malĂŠ humanin-like peptidy 1-6 (SHLP1-6). Ve stresovĂ˝ch situacĂch podporujĂ aktivitu mitochondriĂ napomĂĄhajĂ pĹeĹžitĂ bunÄk; kromÄ toho ovlivĹujĂ metabolismus, odpovÄÄ na stres i zĂĄnÄt jak in vivo, tak vitro. VĂ˝zkum v poslednĂ dobÄ prokĂĄzal, Ĺže hrajĂ vĂ˝znamnou Ăşlohu rozvoji kardiovaskulĂĄrnĂch onemocnÄnĂ (KVO). dalĹĄĂ moĹžnĂŠ faktory ischemie, neĂşspÄĹĄnĂĄ reperfuze, fibrĂłza dysfunkce koronĂĄrnĂ mikrocirkulace. mohou slouĹžit jako markery KVO nebo se stĂĄt cĂlem lĂŠÄby KVO. Do tĂŠto skupiny peptidĹŻ MOTS-c SHLP. Humanin sniĹžuje oxidaÄnĂ cestou inhibice aktivity mitochondriĂĄlnĂho komplexu 1. Je prokĂĄzĂĄno, ĂşÄinnÄ pomĂĄhajĂ lĂŠÄit metabolickĂŠ poruchy vÄetnÄ diabetu 2. typu. mĹŻĹže marker lĂŠÄbÄ pĹĂmo endoteliĂĄlnĂ dysfunkce. Tento pĹehled zabĂ˝vĂĄ novĂ˝mi moĹžnostmi vyuĹžitĂ humaninu jeho biologickĂ˝m vĂ˝znamem
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ژورنال
عنوان ژورنال: Cor et vasa
سال: 2023
ISSN: ['0010-8650', '1803-7712']
DOI: https://doi.org/10.33678/cor.2022.057